Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 19-25 , April 2008

Neonatal Isolation Enhances Anxiety-like Behavior Following Early-life Seizure in Rats

  • Ming-Chi Lai

      Affiliations

    • The Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • Department of Pediatrics, Chi Mei Foundation Hospital, Tainan, Taiwan
    • ,
  • San-Nan Yang

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Li-Tung Huang

      Affiliations

    • Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Chang Gung Memorial Hospital, 123 Ta Pei Road, Niao Sung, Kaohsiung, Taiwan

Received 15 November 2007 ,Revised 2 January 2008 ,Accepted 25 March 2008.

References 

  1. Dube C , Boyet S , Marescaux C , Nehlig A . Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat . Exp Neurol . 2000;162:146–157
  2. Dube C , Boyet S , Marescaux C , Nehlig A . Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat . Exp Neurol . 2001;167:227–241
  3. Lai MC , Liou CW , Yang SN , et al.   Recurrent bicucullineinduced seizures in rat pups cause long-term motor deficits and increase vulnerability to a subsequent insult . Epilepsy Behav . 2002;3:60–66
  4. Sarkisian MR , Tandon P , Liu Z , et al.   Multiple kainic acid seizures in the immature and adult brain: ictal manifestations and long-term effects on learning and memory . Epilepsia . 1997;38:1157–1166
  5. Schmid R , Tandon P , Stafstrom CE , Holmes GL . Effects of neonatal seizures on subsequent seizure-induced brain injury . Neurology . 1999;53:1754–1761
  6. Stafstrom CE , Chronopoulos A , Thurber S , Thompson JL , Holmes GL . Age-dependent cognitive and behavioral deficits after kainic acid seizures . Epilepsia . 1993;34:420–432
  7. Brunson KL , Kramar E , Lin B , et al.   Mechanisms of late-onset cognitive decline after early-life stress . J Neurosci . 2005;25:9328–9338
  8. Dube SR , Anda RF , Felitti VJ , Chapman DP , Williamson DF , Giles WH . Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study . JAMA . 2001;286:3089–3096
  9. Gilmer WS , McKinney WT . Early experience and depressive disorders: human and non-human primate studies . J Affect Disord . 2003;75:97–113
  10. Imanaka A , Morinobu S , Toki S , Yamawaki S . Importance of early environment in the development of post-traumatic stress disorder-like behaviors . Behav Brain Res . 2006;173:129–137
  11. Knuth ED , Etgen AM . Long-term behavioral consequences of brief, repeated neonatal isolation . Brain Res . 2007;1128:139–147
  12. Kosten TA , Karanian DA , Yeh J , et al.   Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience . Neurobiol Learn Mem . 2007;88:167–176
  13. Kosten TA , Miserendino MJ , Kehoe P . Enhanced acqui sition of cocaine self-administration in adult rats with neonatal isolation stress experience . Brain Res . 2000;875:44–50
  14. Lissau I , Sorensen TIA . Parental neglect during childhood and increased risk of obesity in young adulthood . Lancet . 1994;343:324–327
  15. Matthews SG . Early programming of the hypothalamopituitary-adrenal axis . Trends Endocrinol Metab . 2002;13:373–380
  16. McEwen BS . Effects of adverse experiences for brain structure and function . Biol Psychiatry . 2000;48:721–731
  17. Huang LT , Holmes GL , Lai MC , et al.   Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures . Epilepsia . 2002;43:1141–1148
  18. Lai MC , Holmes GL , Lee KH , et al.   Effect of neonatal isolation on outcome following neonatal seizures in rats—the role of corticosterone . Epilepsy Res . 2006;68:123–136
  19. West MJ , King AP . Settling nature and nurture into an ontogenetic niche . Dev Psychobiol . 1987;20:549–562
  20. Avishai-Eliner S , Brunson KL , Sandman CA , Baram TZ . Stressedout, or in (utero)? . Trends Neurosci . 2002;25:518–524
  21. Francis DD , Diorio J , Plotsky PM , Meaney MJ . Environmental enrichment reverses the effects of maternal separation on stress reactivity . J Neurosci . 2002;22:7840–7843
  22. Knuth ED , Etgen AM . Corticosterone secretion induced by chronic isolation in neonatal rats is sexually dimorphic and accompanied by elevated ACTH . Horm Behav . 2005;47:65–75
  23. Levine S . Maternal behavior as a mediator of pup adrenocortical function . Ann NY Acad Sci . 1994;746:260–275
  24. McCormick CM , Kehoe P , Kovacs S . Corticosterone release in response to repeated, short episodes of neonatal isolation: evidence of sensitization . Int J Dev Neurosci . 1998;16:175–185
  25. Meaney MJ . Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations . Annu Rev Neurosci . 2001;24:1161–1192
  26. Weaver IC , Cervoni N , Champagne FA , et al.   Epigenetic programming by maternal behavior . Nat Neurosci . 2004;7:847–854
  27. De Bellis MD . The psychobiology of neglect . Child Maltreat . 2005;10:150–172
  28. McEwen BS . Early life influences on life-long patterns of behavior and health . Ment Retard Dev Disabil Res Rev . 2003;9:149–154
  29. Repetti RL , Taylor SE , Seeman TE . Risky families: family social environments and the mental and physical health of offspring . Psychol Bull . 2002;128:330–366
  30. Becker K , Abraham A , Kindler J , Helmeke C , Braun K . Exposure to neonatal separation stress alters exploratory behavior and corticotropin releasing factor expression in neurons in the amygdala and hippocampus . Dev Neurobiol . 2007;67:617–629
  31. Hatalski CG , Guirguis C , Baram TZ . Corticotropin releasing factor mRNA expression in the hypothalamic paraventricular nucleus and the central nucleus of the amygdala is modulated by repeated acute stress in the immature rat . J Neuroendocrinol . 1998;10:663–669
  32. Plotsky PM , Meaney MJ . Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats . Mol Brain Res . 1993;18:195–200
  33. Pellow S , File SE . Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat . Pharmacol Biochem Behav . 1986;24:525–529
  34. Pellow S , Chopin P , File SE , Briley M . Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat . J Neurosci Methods . 1985;14:149–167
  35. File SE . Factors controlling measures of anxiety and responses to novelty in the mouse . Behav Brain Res . 2001;125:151–157
  36. Clifford DB , Olney JW , Maniotis A , Collins RC , Zorumski CF . The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures . Neuroscience . 1987;23:953–968
  37. Hirsch E , Baram TZ , Snead OC . Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats . Brain Res . 1992;583:120–126
  38. Racine RJ . Modification of seizure activity by electrical stimulation. I. After-discharge threshold . Electroencephalogr Clin Neurophysiol . 1972;32:269–279
  39. Anda RF , Felitti VJ , Bremner JD , et al.   The enduring effects of abuse and related adverse experiences in childhood: a convergence of evidence from neurobiology and epidemiology . Eur Arch Psychiatry Clin Neurosci . 2006;256:174–186
  40. Felitti VJ , Anda RF , Nordenberg D , et al.   Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study . Am J Prev Med . 1998;14:245–258
  41. Nemeroff CB , Widerlov E , Bissette G , et al.   Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients . Science . 1984;226:1342–1344
  42. Albeck DS , McKittrick CR , Blanchard DC , et al.   Chronic social stress alters levels of corticotropin-releasing factor and arginine vasopressin mRNA in rat brain . J Neurosci . 1997;17:4895–4903
  43. Schulkin J . Corticotropin-releasing hormone signals adversity in both the placenta and the brain: regulation by glucocorticoids and allostatic overload . J Endocrinol . 1999;161:349–356
  44. Schulkin J , Gold PW , McEwen BS . Induction of corticotropinreleasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load . Psychoneuroendocrinology . 1998;23:219–243
  45. Bremner JD , Licinio J , Darnell A , et al.   Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder . Am J Psychiatry . 1997;154:624–629
  46. Shepard JD , Myers DA . Strain differences in anxiety-like behavior: association with corticotropin-releasing factor . Behav Brain Res . 2008;186:239–245
  47. Richter RM , Zorrilla EP , Basso AM , Koob GF , Weiss F . Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study . Alcohol Clin Exp Res . 2000;24:1765–1772
  48. Roskoden T , Hanke J , Yilmazer-Hanke D , Schwegler H . Reduced number of CRF-containing neurons in the central amygdala correlated with enhanced locomotor activity following early postnatal corticosterone treatment in the Wistar rat . Behav Brain Res . 2005;165:221–228

PII: S1875-9572(08)60006-6

doi: 10.1016/S1875-9572(08)60006-6

Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 19-25 , April 2008

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