Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 30-34 , April 2008

Association of a Lymphotoxin-α Gene Polymorphism and Atopic Asthma in Taiwanese Children

  • Szu-Chao Huang

      Affiliations

    • Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    • ,
  • Wen-Jun Wu

      Affiliations

    • Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan
    • ,
  • Hai-Lun Sun

      Affiliations

    • Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    • Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    • ,
  • Ko-Huang Lue

      Affiliations

    • Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    • Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    • Corresponding Author InformationCorresponding author. Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, No. 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan
    • ,
  • Chia-Hsiu Hsu

      Affiliations

    • Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    • ,
  • Pei-Fen Liao

      Affiliations

    • Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    • ,
  • Min-Sho Ku

      Affiliations

    • Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan

Received 16 July 2007 ,Revised 22 February 2008 ,Accepted 25 March 2008.

References 

  1. Robison DS , Hamid Q , Ying S , et al.   Predominant Th2-like bronchoalveolar T lymphocyte population in atopic asthma . N Engl J Med . 1992;326:298–304
  2. American Thoracic Society  . Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease and asthma . Am Rev Respir Dis . 1988;136:225–244
  3. Holberg CJ , Elston RC , Halonen M , et al.   Segregation analysis of physician-diagnosed asthma in Hispanic and non-Hispanic white families . Am J Respir Crit Care Med . 1996;154:140–150
  4. European Community Respiratory Health Survey Group  . Gene for asthma? An analysis of the European Community Respiratory Health Survey . Am J Respir Crit Care Med . 1997;156:1773–1780
  5. Wang TN , Ko YC , Wang TH , Li Cheng SH , Lin YC . Segregation analysis of asthma: a recessive major gene component for asthma in relation to history of atopic diseases . Am J Med Genet . 2000;93:373–380
  6. Sears MR , Burrows B , Flannery EM , Herbison GP , Hewitt CJ , Holdaway MD . Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children . N Engl J Med . 1991;325:1067–1071
  7. Shibasaki M , Tajima K , Morikawa A , Mitsuhashi M , Sumazaki R , Tokuyama K . Relation between frequency of asthma and IgE antibody levels against Dermatophagoides farinae and total serum IgE levels in school children . J Allergy Clin Immunol . 1988;82:86–94
  8. Denburg JA . Bone marrow in atopy and asthma: hematopoietic mechanisms in allergic inflammation . Immunol Today . 1999;20:111–113
  9. Busse WW , Lemarke RF . Asthma . N Engl J Med . 2001;344:350–362
  10. Ying S , Robinson DS , Varney V , et al.   TNF α mRNA expression in allergic inflammation . Clin Exp Allergy . 1991;21:745–750
  11. Carroll MC , Katzman P , Alicot EM , et al.   Linkage map of the human major histocompatibility complex including the tumour necrosis factor genes . Proc Natl Acad Sci USA . 1987;84:8535–8539
  12. Albuquerque RV , Hayden CM , Palmer LJ , et al.   Association of polymorphisms within the tumour necrosis factor (TNF) genes and childhood asthma . Clin Exp Allergy . 1998;28:578–584
  13. Messer G , Spengler U , Jung MC , et al.   Polymorphic structure of the tumour necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production . J Exp Med . 1991;173:209–219
  14. Stuber F , Udalova IA , Book M , et al.   -308 Tumor necrosis factor polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccaride inducibility of the human TNF promoter . J Inflamm . 1996;46:42–50
  15. Bidwell J , Keen L , Gallagher G , et al.   Cytokine gene polymorphism in human disease . Genes Immun . 2001;2:61–70
  16. Hoffmann SC , Stanley EM , Cox ED , et al.   Association of cytokine polymorphism inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes . Transplantation . 2001;72:1444–1450
  17. Daniels SE , Bhattacharrya S , James A , et al.   A genome-wide search for quantitative trait loci underlying asthma . Nature . 1996;383:247–250
  18. Wjst M , Fischer G , Immervoll T , et al.   A genome-wide search for linkage to asthma. German Asthma Genetics Group . Genomics . 1999;58:1–8
  19. Ruddle NH , Waksman BH . Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. III. Analysis of mechanism . J Exp Med . 1968;128:1267–1279
  20. Gajewska BU , Alvarez D , Vidric M , et al.   Generation of experimental allergic airways inflammation in the absence of draining lymph nodes . J Clin Invest . 2001;108:577–583
  21. Worm M , Ebermayer K , Henz B . Lymphotoxin-alpha is an important autocrine factor for CD40 interleukin-4-mediated B cell activation in normal and atopic donors . Immunology . 1998;94:395–402
  22. Kang HS , Blink SE , Chin RK , et al.   Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation . J Exp Med . 2003;198:1643–1652
  23. Roach DR , Briscoe H , Saunders B , et al.   Secreted lymphotoxinalpha is essential for the control of an intracellular bacterial infection . J Exp Med . 2001;193:239–246
  24. Engwerda CR , Mynott TL , Sawhney S , et al.   Locally upregulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria . J Exp Med . 2002;195:1371–1377
  25. Ozaki K , Ohnishi Y , Iida A , et al.   Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction . Nat Genet . 2002;32:650–654
  26. Ozaki K , Inoue K , Sato H , et al.   Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro . Nature . 2004;429:72–75
  27. Moffatt MF , Cookson WO . Tumour necrosis factor haplotypes and asthma . Hum Mol Genet . 1997;6:551–554
  28. Wang TN , Chen WY , Wang TH , et al.   Gene-gene synergistic effect on atopic asthma: TNF-α-308 and lymphotoxin-α-NcoI in Taiwan's children . Clin Exp Allergy . 2004;34:184–188
  29. Mochizuki H , Shigeta M , Tokuyama K , et al.   Difference in airway reactivity in children with atopic vs. non-atopic asthma . Chest . 1999;116:619–624
  30. Trabetti E , Patuzzo C , Malerba G , et al.   Association of a lymphotoxin alpha gene polymorphism and atopy in Italian families . J Med Genet . 1999;36:323–325
  31. Lin YC , Lu CC , Su HJ , et al.   The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents . Allergy . 2002;57:831–834
  32. Hansen G , Berry G , Dekruyff RH , et al.   Allergen-specific Th1 cells fails to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation . J Clin Invest . 1999;103:175–183
  33. Randolph DA , Carruthers CJ , Szabo SJ , et al.   Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma . J Immunol . 1999;162:2375–2383
  34. Virchow JC , Walker C , Hafner D , et al.   T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma . Am J Respir Crit Care Med . 1995;151:960–968
  35. Broide DH , Lotz M , Cuomo AJ , et al.   Cytokines in symptomatic asthma airways . J Allergy Clin Immunol . 1992;89:958–967
  36. Malerba G , Trabetti E , Patuzzo C , et al.   Candidate genes and a genome-wide search in Italian families with atopic asthmatic children . Clin Exp Allergy . 1999;29:27–30
  37. Noguchi E , Yokouchi Y , Shibasaki M , et al.   Association between TNFA polymorphism and the development of asthma in the Japanese population . Am J Respir Crit Care Med . 2002;166:43–46
  38. Mogita O , Noguchi E , Shibasaki M , et al.   Haplotype analysis of a 100 kb region spanning TNF-LTA polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan . Clin Exp Allergy . 2005;35:790–796

PII: S1875-9572(08)60008-X

doi: 10.1016/S1875-9572(08)60008-X

Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 30-34 , April 2008

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