Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 35-38, April 2008

Systemic Lupus Erythematosus Associated with Extreme Hypertriglyceridemia

  • Chin-Sung Huang

      Affiliations

    • Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Wei-Fong Wu

      Affiliations

    • Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, No. 10, Section 4, Ren-Ai Road, Taipei, Taiwan

Received 13 July 2007; received in revised form 12 December 2007; accepted 25 March 2008.

Only a few cases of hypertriglyceridemia in patients with systemic lupus erythematosus (SLE) have been reported. We report a case of a 13-year-old girl suffering from SLE associated with severe hypertriglyceridemia. The persistent hypertriglyceridemia was extremely well tolerated. As a result of steroid treatment, serum triglycerides fell dramatically from a high of 5601 mg/dL to 75 mg/dL despite the patient switching to a free diet. We considered the presence of an autoantibody to lipoprotein lipase and commenced immunosuppression. The role of steroids in completely correcting deficient lipoprotein lipase activity is discussed.

KEY WORDS:  hypertriglyceridemia , lipoprotein lipase , systemic lupus erythematosus , type V hyperlipo-proteinemia

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PII: S1875-9572(08)60009-1

doi:10.1016/S1875-9572(08)60009-1

Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 35-38, April 2008

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