Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 35-38, April 2008

Systemic Lupus Erythematosus Associated with Extreme Hypertriglyceridemia

  • Chin-Sung Huang

      Affiliations

    • Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Wei-Fong Wu

      Affiliations

    • Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, No. 10, Section 4, Ren-Ai Road, Taipei, Taiwan

Received 13 July 2007; received in revised form 12 December 2007; accepted 25 March 2008.

Article Outline

Only a few cases of hypertriglyceridemia in patients with systemic lupus erythematosus (SLE) have been reported. We report a case of a 13-year-old girl suffering from SLE associated with severe hypertriglyceridemia. The persistent hypertriglyceridemia was extremely well tolerated. As a result of steroid treatment, serum triglycerides fell dramatically from a high of 5601 mg/dL to 75 mg/dL despite the patient switching to a free diet. We considered the presence of an autoantibody to lipoprotein lipase and commenced immunosuppression. The role of steroids in completely correcting deficient lipoprotein lipase activity is discussed.

KEY WORDS:  hypertriglyceridemia , lipoprotein lipase , systemic lupus erythematosus , type V hyperlipo-proteinemia

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Beaumont JL . Autoimmune hyperlipidemia: an atherogenic metabolic disease of immune origin . Rev Eur Clin Biol . 1970;15:1037–1048
  2. Beaumont JL , Berard M , Antonucci M , Delplanque B , Vranckx R . Inhibition of lipoprotein lipase activity by a monoclonal immunoglobulin in autoimmune hyperlipidemia . Atherosclerosis . 1977;26:67–77
  3. Glueck CJ , Levy RI , Glueck HI , Gralnick HR , Greten H , Fredrickson DS . Acquired type I hyperlipoproteinemia with systemic lupus erythematosus, dysglobulinemia and heparin resistance . Am J Med . 1969;47:318–324
  4. Falko JM , Williams JC , Harvey DG , Weidman SW , Schonfeld G , Dodson WE . Hyperlipoproteinemia and multifocal neurologic dysfunction in systemic lupus erythematosus . J Pediatr . 1979;95:523–529
  5. Paucillo P , De Simone B , Rubba P , Mancini M . A case of association between type I hyperlipoproteinemia and systemic lupus erythematosus (SLE): effects of steroid treatment . J Endocrinol Invest . 1986;9:517–520
  6. Stem MP , Kolterman OG , McDevitt H , Reaven GM . Acquired type 3 hyperlipoproteinemia: report of three cases associated with systemic lupus erythematosus and diabetic ketoacidosis . Arch Intern Med . 1972;130:817–821
  7. Alverson DC , Chase HP . Systemic lupus erythematosus in childhood presenting as hyperlipoproteinemia . J Pediatr . 1977;91:72–75
  8. Nakane T , Asayama K , Higashida K , et al.   Type V hyperlipoproteinemia in systemic lupus erythematosus . Pediatr Int . 2003;45:352–354
  9. Brunzell JD . Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome . In:  Scriver C ,  Beaudet AI ,  Sly WS ,  Valle D editor. The Metabolic and Molecular Basis of Inherited Diseases . New York: McGraw-Hill; 1995;p. 1913–1933
  10. Borba EF , Bonfa E , Vinagre CGC , Ramires JAF , Maranhao RC . Chylomicron metabolism is markedly altered in systemic lupus erythematosus . Arthritis Rheum . 2000;43:1033–1040
  11. Kihara S , Matsuzawa Y , Kubo M , et al.   Autoimmune hyperchylomicronemia . N Engl J Med . 1989;320:1255–1259
  12. Pruneta V , Moulin P , Labrousse F , Bondon P-J , Ponsin G , Berthezene F . Characterization of a new case of autoimmune type I hyperlipidemia: long-term remission under immunosuppressive therapy . J Clin Endocrinol Metab . 1997;82:791–799
  13. Tan EM , Cohen AS , Fries IF , et al.   The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE) . Arthritis Rheum . 1982;25:1271–1277
  14. Beaumont JL , Carlson LA , Cooper GR , Fejfar Z , Fredrickson DS . Classification of hyperlipidemias and hyperlipoproteinemias . Bull World Health Organ . 1970;43:891–915

PII: S1875-9572(08)60009-1

doi:10.1016/S1875-9572(08)60009-1

Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 35-38, April 2008

Article Tools