Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 39-42, April 2008

Macrophage Activation Syndrome as Initial Presentation of Systemic Lupus Erythematosus

Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan

Received 27 November 2007; received in revised form 15 January 2008; accepted 25 March 2008.

Article Outline

Macrophage activation syndrome (MAS) is known to be a severe and potentially life-threatening complication of rheumatic disorder, especially systemic juvenile rheumatoid arthritis. It is very rare for MAS to be an initial presentation of systemic lupus erythematosus (SLE). Here, we report a 14-year-old girl in whom MAS developed as an initial presentation of SLE. With early diagnosis and administration of cyclosporine A, she had a fair outcome. Further testing showed positive anti-dsDNA about 8 months later.

KEY WORDS:  cyclosporine A , macrophage activation syndrome , systemic lupus erythematosus , type V hyperlipo-proteinemia

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PII: S1875-9572(08)60010-8

doi:10.1016/S1875-9572(08)60010-8

Pediatrics & Neonatology
Volume 49, Issue 2 , Pages 39-42, April 2008

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