Pediatrics & Neonatology
Volume 49, Issue 4 , Pages 113-115, August 2008

Enterovirus 71, One Virus and Many Stories

  • Shih-Min Wang

      Affiliations

    • Department of Emergency Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    • ,
  • Tzong-Shiann Ho

      Affiliations

    • Department of Pediatrics, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    • ,
  • Ching-Fen Shen

      Affiliations

    • Department of Pediatrics, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    • ,
  • Ching-Chuan Liu

      Affiliations

    • Department of Pediatrics, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, National Cheng Kung University Medical College and Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan

Received 3 August 2008; received in revised form 27 August 2008; accepted 28 August 2008.

Enterovirus 71 (EV71) has emerged as a significant cause of brainstem encephalitis and acute flaccid paralysis in Taiwan. It may be complicated by autonomic nervous system dysregulation and pulmonary edema (PE). Cytokines in the central nervous system and systemic inflammatory responses play important roles in the pathogenesis of EV71-associated PE. Pathogenesis-based management with intravenous immunoglobulin and milrinone has been associated with reduced mortality in children with severe EV71 infections.

KEY WORDS:  autonomic nervous system dysregulation , brainstem encephalitis , cytokines , enterovirus 71 , pulmonary edema

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PII: S1875-9572(08)60024-8

doi:10.1016/S1875-9572(08)60024-8

Pediatrics & Neonatology
Volume 49, Issue 4 , Pages 113-115, August 2008

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