Pediatrics & Neonatology
Volume 49, Issue 4 , Pages 135-140 , August 2008

Effect of the Chinese Herb Extract Osthol on IL-4-induced Eotaxin Expression in BEAS-2B Cells

  • Pu-Rong Chiu

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Pediatrics, Yuan's General Hospital, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Wei-Te Lee

      Affiliations

    • Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Yu-Te Chu

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Min-Sheng Lee

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Yuh-Jyh Jong

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Chih-Hsing Hung

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan

Received 9 January 2008 ,Revised 20 May 2008 ,Accepted 28 August 2008.

References 

  1. Ko FN , Wu TS , Liou MJ , Huang TF , Teng CM . Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens . Eur J Pharmacol . 1992;219:29–34
  2. Guh JH , Yu SM , Ko FN , Wu TS , Teng CM . Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens . Eur J Pharmacol . 1996;298:191–197
  3. Huang RL , Chen CC , Huang YL , et al.   Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro . Hepatology . 1996;24:508–515
  4. Liu JH , Zschocke S , Reininger E , Bauer R . Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase . Planta Med . 1998;64:525–529
  5. Cai J , Yu B , Xu G , Wu J . Studies on the quality of fructus Cnidii: comparison of antibacterial action . Zhongguo Zhong Yao Za Zhi . 1991;16:451–453
  6. Matsuda H , Tomohiro N , Ido Y , Kubo M . Anti-allergic effects of Cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol . Biol Pharm Bull . 2002;25:809–812
  7. Ellis EF . Asthma in childhood . J Allergy Clin Immunol . 1983;72:526–539
  8. Nadel JA . Inflammation and asthma . J Allergy Clin Immunol . 1984;73:651–653
  9. Metzger WJ , Hunninghake GW , Richerson HB . Late asthmatic responses: inquiry into mechanisms and significance . Clin Rev Allergy . 1985;3:145–165
  10. Leff AR , Hamann KJ , Wegner CD . Inflammation and cellcell interactions in airway hyperresponsiveness . Am J Physiol . 1991;260:L189–L206
  11. Bochner BS , Schleimer RP . The role of adhesion molecules in human eosinophil and basophil recruitment . J Allergy Clin Immunol . 1994;94:427–438
  12. Rothenberg ME , MacLean JA , Pearlman E , Luster AD , Leder P . Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia . J Exp Med . 1997;185:785–790
  13. Foster PS , Mould AW , Yang M , et al.   Elemental signals regulating eosinophil accumulation in the lung . Immunol Rev . 2001;179:173–181
  14. Fujisawa T , Kato Y , Atsuta J , et al.   Chemokine production by the BEAS-2B human bronchial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by TH2- and TH1-derived cytokines . J Allergy Clin Immunol . 2000;105:126–133
  15. Upton MN , McConnachie A , McSharry C , et al.   Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring . BMJ . 2000;321:88–92
  16. Herrick CA , Bottomly K . To respond or not to respond: T cells in allergic asthma . Nat Rev Immunol . 2003;3:405–412
  17. Tobin MJ . Asthma, airway biology, and allergic rhinitis in AJRCCM 2000 . Am J Respir Crit Care Med . 2001;164:1559–1580
  18. Liard R , Leynaert B , Zureik M , Beguin FX , Neukirch F . Using Global Initiative for Asthma guidelines to assess asthma severity in populations . Eur Respir J . 2000;16:615–620
  19. Rankin SM , Conroy DM , Williams TJ . Eotaxin and eosinophil recruitment: implications for human disease . Mol Med Today . 2000;6:20–27
  20. Chiappara G , Gagliardo R , Siena A , et al.   Airway remodeling in the pathogenesis of asthma . Curr Opin Allergy Clin Immunol . 2001;1:85–93
  21. Damera G , Xia B , Sachdev GP . IL-4 induced MUC4 enhancement in respiratory epithelial cells in vitro is mediated through JAK-3 selective signaling . Respir Res . 2006;7:39–50
  22. Chang L , Karin M . Mammalian MAP kinase signalling cascades . Nature . 2001;410:37–40
  23. Shuai K , Liu B . Regulation of JAK-STAT signaling in the immune system . Nat Rev Immunol . 2003;3:900–911
  24. Li XX , Hara I , Matsumiya T . Effects of osthole on postmenopausal osteoporosis using ovariectomized rats: comparison to the effects of estradiol . Biol Pharm Bull . 2002;25:738–742

PII: S1875-9572(08)60028-5

doi: 10.1016/S1875-9572(08)60028-5

Pediatrics & Neonatology
Volume 49, Issue 4 , Pages 135-140 , August 2008

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