Pediatrics & Neonatology
Volume 49, Issue 4 , Pages 141-144, August 2008

Treatment with High-dose Methylprednisolone for Hepatic Veno-occlusive Disease in a Child with Rhabdomyosarcoma

  • I-Lun Chen

      Affiliations

    • Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • San-Nan Yang

      Affiliations

    • Department of Pediatrics and Graduate Institute of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan
    • ,
  • Chih-Cheng Hsiao

      Affiliations

    • Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • Kuan-Sheng Wu

      Affiliations

    • Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • Jiunn-Ming Sheen

      Affiliations

    • Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan

Received 30 August 2007; received in revised form 26 February 2008; accepted 28 August 2008.

Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome, is rapidly progressing and involves life-threatening complications that can occur in patients receiving chemotherapy and/or bone marrow transplantation. No completely satisfactory treatment strategies have yet been established. We present a case of rhabdomyosarcoma in a 21-month-old boy who developed pancytopenia, dyspnea, jaundice, massive ascites and body weight gain of more than 10% after receiving conventional chemotherapy. Hepatic VOD was diagnosed. He recovered after supportive care and treatment with high-dose methylprednisolone.

KEY WORDS:  chemotherapy , child , methylprednisolone , rhabdomyosarcoma , veno-occlusive disease

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PII: S1875-9572(08)60029-7

doi:10.1016/S1875-9572(08)60029-7

Pediatrics & Neonatology
Volume 49, Issue 4 , Pages 141-144, August 2008

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