Pediatrics & Neonatology
Volume 49, Issue 5 , Pages 201-204 , October 2008

Valproate-induced Hyperammonemic Encephalopathy

  • Hsiao-Feng Chou

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Pediatrics, Tian-Sheng Memorial Hospital, Pingtung, Taiwan
    • ,
  • Rei-Cheng Yang

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Cheng Ying Chen

      Affiliations

    • Department of Nephrology, Tian-Sheng Memorial Hospital, Pingtung, Taiwan
    • ,
  • Yuh-Jyh Jong

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Kaoshung Medical University Hospital, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan

Received 21 May 2008 ,Revised 4 August 2008 ,Accepted 19 September 2008.

References 

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  3. Iinuma K , Hayasaka K , Narisawa K , Tada K , Hori K . Hyperaminoacidemia and hyperammonemia in epileptic children treated with valproic acid . Eur J Pediatr . 1988;148:267–269
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  13. Eyer F , Felgenhauer N , Gempel K , Steimer W , Gerbitz KD , Zilker T . Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy . J Clin Psychopharmacol . 2005;25:376–380
  14. Chen WT , Yen DJ , Yu HY , Liao KK . Valproate-induced encephalopathy . Chin Med J . 2001;64:474–478
  15. Singh S , McCormick BB , Mustata S , Thompson M , Prasad GVR . Extracorporeal management of valproic acid overdose: a large regional experience . J Nephrol . 2004;17:43–49
  16. Weng TI , Shih FY , Chen WJ . Unusual causes of hyperammonemia in the ED . Am J Emerg Med . 2004;22:105–107

PII: S1875-9572(09)60010-3

doi: 10.1016/S1875-9572(09)60010-3

Pediatrics & Neonatology
Volume 49, Issue 5 , Pages 201-204 , October 2008

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