Pediatrics & Neonatology
Volume 49, Issue 6 , Pages 213-217, December 2008

Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation

  • Jao-Shwann Liang

      Affiliations

    • International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, Taiwan
    • Department of Pediatrics, Far Eastern Memorial Hospital, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Far Eastern Memorial Hospital, 21 Nanya South Road, Section 2, Panchiao City, Taipei 22060, Taiwan
    • ,
  • Keiko Shimojima

      Affiliations

    • International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, Taiwan
    • ,
  • Toshiyuki Yamamoto

      Affiliations

    • International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, Taiwan

Received 23 July 2008; received in revised form 25 September 2008; accepted 25 October 2008.

Article Outline

Children with developmental delay or mental retardation (DD/MR) are commonly en countered in child neurology clinics, and establishing an etiologic diagnosis is a challenge for child neurologists. Among the etiologies, chromosomal imbalance is one of the most important causes. However, many of these chromosomal imbalances are submicroscopic and cannot be detected by conventional cytogenetic methods. Microarray-based comparative genomic hybridization (array CGH) is considered to be superior in the investigation of chromosomal deletions or duplications in children with DD/MR, and has been demonstrated to improve the diagnostic detection rate for these small chromosomal abnormalities. Here, we review the recent studies of array CGH in the evaluation of patients with idiopathic DD/MR.

Key Words:  array-based comparative genomic hybridization , cytogenic test , developmental delay , mental retardation

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PII: S1875-9572(09)60013-9

doi:10.1016/S1875-9572(09)60013-9

Pediatrics & Neonatology
Volume 49, Issue 6 , Pages 213-217, December 2008

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