Pediatrics & Neonatology
Volume 50, Issue 2 , Pages 50-53 , April 2009

Effects of Maternal Undernutrition on Glomerular Ultrastructure in Rat Offspring

  • Chung-Ming Chen

      Affiliations

    • Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Taipei Medical University Hospital, 252 Wu-Hsing Street, Taipei 110, Taiwan
    • ,
  • Hsiu-Chu Chou

      Affiliations

    • Department of Anatomy, College of Medicine, Taipei, Taiwan

Received 14 March 2008 ,Revised 25 June 2008 ,Accepted 23 September 2008.

References 

  1. Barker DJP . The fetal origins of hypertension . J Hypertens . 1996;14:S117–S120
  2. Moore VM , Miller AG , Boulton TJC , et al.   Placental weight, birth measurements and blood pressure at age 8 years . Arch Dis Child . 1996;74:538–541
  3. Rich-Edwards JW , Stampter MJ , Manson JE , et al.   Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976 . Br Med J . 1997;315:396–400
  4. Marchand MC , Langley-Evans SC . Intrauterine programming of nephron number: the fetal flaw revisited . J Nephrol . 2001;14:327–331
  5. Clark PM . Programming of the hypothalamo-pituitary-adrenal axis and the fetal origins of adult disease hypothesis . Eur J Pediatr . 1998;157:S7–10
  6. Vehaskari VM , Alives DH , Manning J . Prenatal programming of adult hypertension in the rat . Kidney Int . 2001;59:238–245
  7. Lucas SRR , Costa Silva VL , Miraglia SM , Zaladek GF . Functional and morphometric evaluation of offspring kidney after intrauterine undernutrition . Pediatr Nephrol . 1997;11:719–723
  8. Manalich R , Reyes L , Herrera M , Melendi C , Fundora I . Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study . Kidney Int . 2000;58:770–773
  9. Chou HS , Wang LF , Lu KS , Chen CM . Effects of maternal undernutrition on renal angiotensin II and chymase in hypertensive offspring . Acta Histochem . 2008;110:497–504
  10. Pagtalunan ME , Rasch R , Rennke HG , Meyer TW . Morpho-metric analysis of effects of angiotensin II on glomerular structure in rats . Am J Physiol . 1995;268:F82–F88
  11. Dische FE . Measurement of GBM thickness and its application to the diagnosis of thin-membrane nephropathy . Arch Pathol Lab Med . 1992;116:43–49
  12. Moritz KM , Dodic M , Wintour EM . Kidney development and the fetal programming of adult disease . Bioessays . 2003;25:212–220
  13. Brenner BM , Garcia DL , Anderson S . Glomeruli and blood pressure: less of one, more the other? . Am J Hypertens . 1988;1:335–347
  14. Lucas SRR , Miraglia SM , Zaladek Gil F , Coimbra TM . Intrauterine food restriction as a determinant of nephro-sclerosis . Am J Kidney Dis . 2001;37:467–476
  15. Drumond MC , Kristal B , Myers BD , Deen WM . Structural basis for reduced glomerular filtration capacity in nephro-tic humans . J Clin Invest . 1994;94:1187–1195
  16. Rudberg S , Osterby R . Decreasing glomerular filtration rate: an indicator of more advanced diabetic glomerulopa-thy in the early course of microalbuminuria in IDDM adolescents? . Nephrol Dial Transplant . 1997;12:1149–1154
  17. Christensen PK , Larsen S , Horn T , Olsen S , Parving HH . Renal function and structure in albuminuric type 2 diabetic patients without retinopathy . Nephrol Dial Transplant . 2001;16:2337–2347

PII: S1875-9572(09)60032-2

doi: 10.1016/S1875-9572(09)60032-2

Pediatrics & Neonatology
Volume 50, Issue 2 , Pages 50-53 , April 2009

Article Tools