Pediatrics & Neonatology
Volume 50, Issue 2 , Pages 65-69, April 2009

Emerging Importance of Autoimmune Hepatitis in Children in Taiwan, an Endemic Area for Viral Hepatitis

  • Sheng-Hsiung Yeh

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Yen-Hsuan Ni

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Yung-Ming Jeng

      Affiliations

    • Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Huey-Ling Chen

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Jia-Feng Wu

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Mei-Hwei Chang

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan

Received 3 June 2008; received in revised form 19 September 2008; accepted 15 October 2008.

Background

Untreated autoimmune hepatitis (AIH) can develop into liver cirrhosis, with potentially fatal outcomes. Viral hepatitis in children was endemic in Taiwan before universal hepatitis B vaccination, but AIH has rarely been reported in Taiwanese children. We performed this retrospective study to characterize the clinical features of AIH in Taiwanese children.

Methods

We enrolled children with AIH, based on the revised scoring system of the International Autoimmune Hepatitis Group (IAIHG) from 383 children hospitalized with hepatitis from January 2000 to April 2008. Other etiologies of hepatitis were excluded.

Results

There were three definite and six probable AIH cases. The incidence of AIH among children hospitalized with hepatitis was 2.3%. Eight children had other autoimmune diseases, including systemic lupus erythematosus (SLE) (6), discoid lupus erythematosus (DLE) (1), and autoimmune polyendocrinopathy syndrome type 1 (1). Another had biliary atresia, and AIH developed after cadaveric liver transplantation. Antinuclear antibodies ranged from 1:160-1:2560. Peak alanine aminotransferase (ALT) values were 546 ± 188 U/L (mean ± SD). Jaundice occurred in four patients. Liver histology in the three definite AIH patients showed chronic hepatitis with predominantly lymphoplasmacytic infiltrates in portal areas, with prominent interface activity. Treatment included prednisolone, azathioprine, and/or cyclosporine. All patients survived. ALT fell to < 60 U/L after treatment. Hepatitis relapse occurred in one patient.

Conclusion

AIH in Taiwanese children is commoner than previously thought. It is associated with other autoimmune diseases and may occur before, simultaneously with, or after other autoimmune diseases. Children with liver transplants are also at risk of AIH.

Key Words:  autoimmune hepatitis , children , liver transplantation , Taiwan

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PII: S1875-9572(09)60035-8

doi:10.1016/S1875-9572(09)60035-8

Pediatrics & Neonatology
Volume 50, Issue 2 , Pages 65-69, April 2009

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