Pediatrics & Neonatology
Volume 50, Issue 4 , Pages 143-146 , August 2009

Neonatal and Pregnancy Outcome in Primary Antiphospholipid Syndrome: A 10-year Experience in One Medical Center

  • An-Kuo Chou

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • Department of Pediatrics, National Taiwan University Hospital, Yun-Lin Branch, Douliu, Taiwan
    • ,
  • Song-Chou Hsieh

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Yi-Ning Su

      Affiliations

    • Department of Obstetrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Suh-Fang Jeng

      Affiliations

    • School and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Chien-Yi Chen

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Hung-Chieh Chou

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Po-Nien Tsao

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Wu-Shiun Hsieh

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan S. Road, Taipei 100, Taiwan, ROC

Received 7 August 2008 ,Revised 24 October 2008 ,Accepted 13 November 2008.

References 

  1. Branch DW , Khamashta MA . Antiphospholipid syndrome: obstetric diagnosis, management, and controversies . Obstet Gynecol . 2003;101:1333–1344
  2. Brewster JA , Shaw NJ , Farquharson RG . Neonatal and pediatric outcome of infants born to mothers with antiphospholipid syndrome . J Perinat Med . 1999;27:183–187
  3. Backos M , Rai R , Baxter N , Chilcott IT , Cohen H , Regan L . Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low dose aspirin and heparin . Br J Obstet Gynaecol . 1999;106:102–107
  4. de Klerk OL , de Vries TW , Sinnige LG . An unusual cause of neonatal seizures in a newborn infant . Pediatrics . 1997;100:E8
  5. Silver RK , MacGregor SN , Pasternak JF , Neely SE . Fetal stroke associated with elevated maternal anticardiolipin antibodies . Obstet Gynecol . 1992;80(3 Pt 2):497–499
  6. Miyakis S , Lockshin MD , Atsumi T , et al.   International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) . J Thromb Haemost . 2006;4:295–306
  7. Hsieh WS , Wu HC , Jeng SF , et al.   Nationwide singleton birth weight percentiles by gestational age in Taiwan, 1998–2002 . Acta Paediatr Taiwanica . 2006;47:25–33
  8. Oshiro BT , Silver RM , Scott JR , Yu H , Branch DW . Antiphospholipid antibodies and fetal death . Obstet Gynecol . 1996;87:489–493
  9. Borrelli AL , Brillante M , Borzacchiello C , Berlingieri P . Hemocoagulative pathology and immunological recurrent abortion . Clin Exp Obstet Gynecol . 1997;24:39–40
  10. Tincani A , Spatola L , Cinquini M , Meroni P , Balestrieri G , Shoenfeld Y . Animal models of antiphospholipid syndrome . Rev Rhum Engl Ed . 1998;65:614–618
  11. Rote NS , Vogt E , DeVere G , Obringer AR , Ng AK . The role of placental trophoblast in the pathophysiology of the antiphospholipid antibody syndrome . Am J Reprod Immunol . 1998;39:125–136
  12. Di Simone N , Meroni PL , de Papa N , et al.   Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I . Arthritis Rheum . 2000;43:140–150
  13. Lockshin MD . Antiphospholipid antibody. Babies, blood clots, biology . JAMA . 1997;277:1549–1551
  14. Girardi G , Berman J , Redecha P , et al.   Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome . J Clin Invest . 2003;112:1644–1654
  15. Tincani A , Lojacono A , Taglietti M , et al.   Pregnancy and neonatal outcome in primary antiphospholipid syndrome . Lupus . 2002;11:649
  16. Tabbutt S , Griswold WR , Ogino MT , Mendoza AE , Allen JB , Reznik VM . Multiple thromboses in a premature infant associated with maternal phospholipid antibody syndrome . J Perinatol . 1994;14:66–70
  17. Galli M , Finazzi G , Barbui T . Thrombocytopenia in the antiphospholipid syndrome: pathophysiology, clinical relevance and treatment . Ann Med Interne (Paris) . 1996;147(Suppl 1):24–27
  18. Godeau B , Piette JC , Fromont P , Intrator L , Schaeffer A , Bierling P . Specific antiplatelet glycoprotein autoantibodies are associated with the thrombocytopenia of primary antiphospholipid syndrome . Br J Haematol . 1997;98:873–879
  19. Panzer S , Gschwandtner ME , Hutter D , Spitzauer S , Pabinger I . Specificities of platelet autoantibodies in patients with lupus anticoagulants in primary antiphospholipid syndrome . Ann Hematol . 1997;74:239–242
  20. Lopez-Soto A , Cervera R , Font J , et al.   Isotype distribution and clinical significance of antibodies to cardiolipin, phosphatidic acid, phosphatidylinositol and phosphatidylserine in systemic lupus erythematosus: prospective analysis of a series of 92 patients . Clin Exper Rheumatol . 1997;15:143–149

PII: S1875-9572(09)60052-8

doi: 10.1016/S1875-9572(09)60052-8

Pediatrics & Neonatology
Volume 50, Issue 4 , Pages 143-146 , August 2009

Article Tools