Pediatrics & Neonatology
Volume 50, Issue 4 , Pages 173-176, August 2009

Retroperitoneal Ganglioneuroma in Childhood—A Presentation of Two Cases

  • Vahudin Zugor

      Affiliations

    • Department of Urology, St. Antonius Hospital, Gronau, Germany
  • ,
  • Günter E. Schott

      Affiliations

    • Department of Urology, University of Erlangen Medical Center, Erlangen, Germany
  • ,
  • Reinhard Kühn

      Affiliations

    • Department of Urology, Martha Maria Medical Center, Nuremberg, Germany
  • ,
  • Apostolos P. Labanaris

      Affiliations

    • Department of Urology, Martha Maria Medical Center, Nuremberg, Germany
    • Corresponding Author InformationCorresponding author. Department of Urology, Martha Maria Medical Center, Stadenstrasse 58, 90409 Nürnberg, Germany

Received 15 July 2008; received in revised form 1 December 2008; accepted 20 February 2009.

Article Outline

Ganglioneuromas are considered to be part of the neuroblastoma series of tumors, which evolve from the sympathogonia of neural crest origin. As imaging techniques have become more widely practiced, the number of ganglioneuromas detected incidentally has increased. Preoperative diagnosis of retroperitoneal ganglioneuromas is often difficult and the diagnosis is usually based on histopathological findings after surgical excision of the tumor. We present two cases of this unique disease entity and discuss its clinical presentation, therapeutic approach, and clinical outcome.

Key Words:  childhood , retroperitoneal ganglioneuroma , therapeutic approach

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Hayes FA , Green AA , Rao BN . Clinical manifestations of ganglioneuroma . Cancer . 1989;63:1211–1214
  2. Lee JY , Lee KS , Han J , et al.   Spectrum of neurogenic tumors in the thorax: CT and pathologic findings . J Comput Assist Tomogr . 1999;23:399–406
  3. Singh KJ , Suri A , Vijjan V , Singh P , Srivastava  . A Retroperitoneal ganglioneuroma presenting as right renal mass . Urology . 2006;67:1085–1088
  4. Yamaguchi K , Hara I , Takeda M , et al.   Two cases of ganglioneuroma . Urology . 2006;67:622–624
  5. Strollo DC , Rosado-de-Christenson LML , Jett JR . Primary mediastinal tumors part II. Tumors of the middle and posterior mediastinum . Chest . 1997;112:1344–1357
  6. Hazarika D , Naresh KN , Clementina RR . Parapharyngeal ganglioneuroma. Report of a case diagnosed by fine needle aspiration cytology . Acta Cytol . 1993;37:552–554
  7. Bjellerup P , Theodorsson E , Kogner P . Somatostatin and vasoactive intestinal peptide in neuroblastoma and ganglioneuroma: chromatographic characterization and release during surgery . Eur J Cancer . 1995;31:481–485
  8. Gentile S , Rainero I , Luda E , Pinessi L . Autonomic dysfunction associated with multiple pelvic ganglioneuromas . Acta Neurol Scand . 2001;104:54–56
  9. Enzinger FM , Weiss SW . Tumors of the sympathetic nervous system . In: Soft tissue Tumors . 3rd ed. St. Louis: C.V. Mosby; 1995;p. 942–944
  10. Dellinger GW , Lynch CA , Mihas AA . Colonic ganglioneuroma presenting as filiform polyposis . J Clin Gastroenterol . 1996;22:66–70
  11. Halloway KB , Flowers FP . Multiple endocrine neoplasia IIb (MEN IIb/MEN 3) . Dermatol Clin . 1995;13:99–103
  12. Hammond RR , Walton JC . Cutaneous ganglioneuromas: a case report and review of the literature . Hum Pathol . 1996;27:735–738
  13. Kleihues P , Cavenee WK . Classification of tumors, pathology and genetics of tumors of the nervous system . World Health Organization, Lyon . 2000;153–161
  14. Otal P , Mezghani S , Hassissene S , et al.   Imaging of retroperitoneal ganglioneuroma . Eur Radiol . 2001;11:940–945
  15. Kulkarni AV , Bilbao JM , Cusimano MD , Miller PJ . Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult . J Neurosurg . 1998;88:324–327
  16. Drago G , Pasquier B , Pasquier D . Malignant peripheral nerve sheath tumour arising in a “de nova” ganglioneuroma: a case report and review of the literature . Med Pediatr Oncol . 1997;28:216–222
  17. Geoerger B , Hero B , Harms D , et al.   Metabolic activity and clinical features of primary ganglioneuromas . Cancer . 2001;91:1905–1913

PII: S1875-9572(09)60058-9

doi:10.1016/S1875-9572(09)60058-9

Pediatrics & Neonatology
Volume 50, Issue 4 , Pages 173-176, August 2009