Pediatrics & Neonatology
Volume 50, Issue 5 , Pages 208-216 , October 2009

Human Umbilical Cord Blood Cells Protect Against Hypothalamic Apoptosis and Systemic Inflammation Response During Heatstroke in Rats

  • Won-Shiung Liu

      Affiliations

    • Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Chun-Ta Chen

      Affiliations

    • Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Ning-Hui Foo

      Affiliations

    • Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Hsuan-Rong Huang

      Affiliations

    • Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Jhi-Joung Wang

      Affiliations

    • Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Sheng-Hsien Chen

      Affiliations

    • Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    • Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan
    • Corresponding Author InformationCorresponding authors. Department of Obstetrics and Gynecology; Department of Pediatrics, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan, Taiwan
    • ,
  • Te-Jen Chen

      Affiliations

    • Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
    • Corresponding Author InformationCorresponding authors. Department of Obstetrics and Gynecology; Department of Pediatrics, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan, Taiwan

Received 25 November 2008 ,Revised 7 January 2009 ,Accepted 19 January 2009.

References 

  1. Bouchama A , Knochel JP . Heat stroke . N Engl J Med . 2002;346:1978–1988
  2. Shen KH , Lin CH , Chang HK , Chen WC , Chen SH . Premarin can act via estrogen receptors to rescue mice from heat-stroke-induced lethality . Shock . 2008;30:668–674
  3. Morecroft JA , Spitz L . The role of inflammatory mediators in necrotizing enterocolitis . Semin Neonatol . 1997;2:273–280
  4. Menger MD , Vollmar B . Adhesion molecules as determinants of disease: from molecular biology to surgical research . Br J Surg . 1996;83:588–601
  5. Boldt J , Wollbruck M , Kuhn D , Linke LC , Hempelmann G . Do plasma levels of circulating soluble adhesion molecules differ between surviving and nonsurviving critically ill patients? . Chest . 1995;107:787–792
  6. Lasky LA . Selectin-carbohydrate interactions and the initiation of the inflammatory response . Annu Rev Biochem . 1995;64:113–139
  7. Kansas GS . Selectins and their ligands: current concepts and controversies . Blood . 1999;88:3259–3287
  8. Varki A . Selectin ligands . Proc Natl Acad Sci USA . 1994;91:7390–7397
  9. Etzioni A . Adhesion molecules: their role in health and disease . Pediatr Res . 1996;39:191–198
  10. Endo S , Inada K , Kasai T , et al.   Levels of soluble adhesion molecules and cytokines in patients with septic multiple organ failure . J Inflamm . 1995;46:212–219
  11. Goda K , Tanaka T , Monden M , Miyasaka M . Characterization of an apparently conserved epitope in E-and P-selectin identified by dual-specific monoclonal antibodies . Eur J Immunol . 1999;29:1551–1560
  12. Lewis ID . Clinical and experimental uses of umbilical cord blood . Intern Med J . 2002;32:601–609
  13. Chen J , Sanberg PR , Li Y , et al.   Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats . Stroke . 2001;32:2682–2688
  14. Lu D , Sanberg PR , Mahmood A , et al.   Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury . Cell Transplant . 2002;11:275–281
  15. Saporta S , Kim JJ , Willing AE , Fu ES , Davis CD , Sanberg PR . Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior . J Hematother Stem Cell Res . 2003;12:271–278
  16. Willing AE , Lixian J , Milliken M , et al.   Intravenous versus intrastriatal cord blood administration in a rodent model of stroke . J Neurosci Res . 2003;73:296–307
  17. Chen SH , Chang FM , Tsai YC , Huang KF , Lin MT . Resuscitation from experimental heatstroke by transplantation of human umbilical cord blood cells . Crit Care Med . 2005;33:1377–1383
  18. Chen SH , Chang FM , Tsai YC , Huang KF , Lin CL , Lin MT . Infusion of human umbilical cord blood cells protect against cerebral ischemia and damage during heatstroke in the rat . Exp Neurol . 2006;199:67–76
  19. Pulsinelli WA , Levy DE , Duffy TE . Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia . Ann Neurol . 1982;11:499–509
  20. Epstein Y , Moran DS , Shapiro Y , Sohar E , Shemer J . Exertional heat stroke: a case series . Med Sci Sports Exerc . 1999;31:224–228
  21. Epstein Y , Sohar E , Shapiro Y . Exertional heatstroke: a preventable condition . Isr J Med Sci . 1995;31:454–462
  22. Shibolet S , Coll R , Gilat T , Sohar E . Heatstroke: its clinical picture and mechanism in 36 cases . Q J Med . 1967;36:525–548
  23. Shapiro Y , Rosenthal T , Sohar E . Experimental heatstroke: model in dogs . Arch Intern Med . 1973;131:688–692
  24. Dematte JE , O'Mara K , Buescher J , et al.   Near-fatal heat stroke during the 1995 heat wave in Chicago . Ann Intern Med . 1998;129:173–181
  25. Knochel JP , Reed G . Disorder of heat regulation . In:  Maxwell MH ,  Kleeman CR ,  Martin RG editor. Clinical Disorder of Fluid and Electrolyte Metabolism . 5th ed. New York: McGraw-Hill; 1994;p. 1549–1590
  26. Bouchama A , Cafege A , Devol EB , Labdi O , el Assil K , Seraj M . Ineffectiveness of dantrolene sodium in the treatment of heatstroke . Crit Care Med . 1991;19:176–180
  27. Bynum GD , Pandolf KB , Schuette WH , et al.   Induced hyperthermia in sedated humans and the concept of critical thermal maximum . Am J Physiol . 1978;235:R228–R236
  28. Pettigrew RT , Galt JM , Ludgate CM , Horn DB , Smith AN . Circulatory and biochemical effects of whole-body hyperthermia . Br J Surg . 1974;61:727–730
  29. Chang CK , Chang CP , Chiu WT , Lin MT . Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke . Curr Med Chem . 2006;13:3145–3154
  30. Leon LR , Blaha MD , DuBose DA . Time course of cytokine, cortico sterone, and tissue injury responses in mice during heat strain recovery . J Appl Physiol . 2006;100:1400–1409
  31. Chatterjee S , Premachandran S , Bagewadikar RS , Bhattacharya S , Chattopadhyay S , Poduval TB . Arginine metabolic pathways determine its therapeutic benefit in experimental heatstroke: role of Th1/Th2 cytokine balance . Nitric Oxide . 2006;15:408–416
  32. Chatterjee S , Premachandran S , Sharma D , Bagewadikar RS , Poduval TB . Therapeutic treatment with L-arginine rescues mice from heat stroke-induced death: physiological and molecular mechanisms . Shock . 2005;24:341–347
  33. Vendrame M , Cassady J , Newcomb J , et al.   Infusion of human umbilical cord blood cells in a rat model of stroke dosedependently rescues behavioral deficits and reduces infarct volume . Stroke . 2004;35:2390–2395
  34. Zigova T , Song S , Willing AE , et al.   Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain . Cell Transplant . 2002;11:265–274
  35. Bouchama A , Parhar RS , el Yazigi A , Sheth K , al Sedairy S . Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke . J Appl Physiol . 1991;70:2640–2644
  36. Chang DM . The role of cytokines in heat stroke . Immunol Invest . 1993;22:553–561
  37. Bouchama A , al Sedairy S , Siddiqui S , Shail E , Rezeig M . Elevated pyrogenic cytokines in heatstroke . Chest . 1993;104:1498–1502
  38. Hammami MM , Bouchama A , Shail E , al Sedairy S . Elevated serum level of soluble interleukin-2 receptor in heatstroke . Intensive Care Med . 1998;24:988
  39. Lin MT , Liu HH , Yang YL . Involvement of interleukin-1 receptor mechanisms in development of arterial hypotension in rat heatstroke . Am J Physiol . 1997;273:H2072–H2077
  40. Lin MT , Kao TY , Su CF , Hsu SS . Interleukin-1 beta production during the onset of heat stroke in rabbits . Neurosci Lett . 1994;174:17–20
  41. Rennick DM , Fort MM , Davidson NJ . Studies with IL-10-/-mice: an overview . J Leukoc Biol . 1997;61:389–396
  42. Berg DJ , Kuhn R , Rajewsky K , et al.   Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance . J Clin Invest . 1995;96:2339–2347
  43. Gerard C , Bruyns C , Marchant A , et al.   Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia . J Exp Med . 1993;177:547–550
  44. Standiford TJ , Strieter RM , Lukacs NW , Kunkel SL . Neutralization of IL-10 increases lethality in endotoxemia: cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor . J Immunol . 1995;155:2222–2229
  45. Liu CC , Chien CH , Lin MT . Glucocorticoids reduce interleukin-1 concentration and result in neuroprotective effects in rat heatstroke . J Physiol . 2000;527:333–343
  46. Wyble CW , Desai TR , Clark ET , Hynes KL , Gewertz BL . Physiologic concentrations of TNFalpha and IL-1beta released from reperfused human intestine upregulate E-selectin and ICAM-1 . J Surg Res . 1996;63:333–338
  47. Menger MD , Vollmar B . Adhesion molecules as determinants of disease: from molecular biology to surgical research . Br J Surg . 1996;83:588–601
  48. Hogg N , Bates PA , Harvey J . Structure and function of intercellular adhesion molecule-1 . Chem Immunol . 1991;50:98–115
  49. Chen LW , Egan L , Li ZW , Greten FR , Kagnoff MF , Karin M . The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion . Nat Med . 2003;9:575–581
  50. Kuzu MA , Koksoy C , Kuzu I , Gurhan I , Ergun H , Demirpence E . Role of integrins and intracellular adhesion molecule-1 in lung injury after intestinal ischemia-reperfusion . Am J Surg . 2002;183:70–74
  51. Olanders K , Sun Z , Borjesson A , et al.   The effect of intestinal ischemia and reperfusion injury on ICAM-1 expression, endothelial barrier function, neutrophil tissue influx, and protease inhibitor levels in rats . Shock . 2002;18:86–92
  52. Bevilacqua MP , Pober JS , Mendrick DL , Cotran RS , Gimbrone MA . Identification of an inducible endothelial-leukocyte adhesion molecule . Proc Natl Acad Sci USA . 1987;84:9238–9242
  53. Phillips ML , Nudelman E , Gaeta FC , et al.   ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex . Science . 1990;250:1130–1132
  54. Bevilacqua MP , Nelson RM , Mannori G , Cecconi O . Endothelial-leukocyte adhesion molecules in human disease . Annu Rev Med . 1994;45:361–378
  55. Yoshida M , Westlin WF , Wang N , et al.   Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton . J Cell Biol . 1996;133:445–455

PII: S1875-9572(09)60065-6

doi: 10.1016/S1875-9572(09)60065-6

Pediatrics & Neonatology
Volume 50, Issue 5 , Pages 208-216 , October 2009

Article Tools