Pediatrics & Neonatology
Volume 50, Issue 6 , Pages 255-260 , December 2009

Association of Cord Plasma Leptin With Birth Size in Term Newborns

  • Wing-Kuen Tung

      Affiliations

    • Department of Pediatrics, Chi Mei Foundation Hospital, Tainan County, Taiwan
  • ,
  • Shio-Jean Lin

      Affiliations

    • Department of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
  • ,
  • Yea-Shwu Hwang

      Affiliations

    • Department of Occupational Therapy, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
  • ,
  • Ching-Ming Wu

      Affiliations

    • Department of Cell Biology and Anatomy, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
  • ,
  • Yun-Han Wang

      Affiliations

    • Department of Science and Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan
  • ,
  • Wen-Hui Tsai

      Affiliations

    • Department of Pediatrics, Chi Mei Foundation Hospital, Tainan County, Taiwan
    • Institute of Clinical Medicine, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Chi-Mei Foundation Hospital, 901 Chung-Hwa Road, Yung Kang, Tainan County, Taiwan

Received 25 November 2008 ,Revised 23 December 2008 ,Accepted 12 February 2009.

References 

  1. Wauters M , Considine RV , Van Gaal LF . Human leptin: from an adipocyte hormone to an endocrine mediator . Eur J Endocrinol . 2000;143:293–311
  2. Stephens TW , Basinski M , Bristow PK , et al.   The role of neuropeptide Y in the antiobesity action of the obese gene product . Nature . 1995;377:530–532
  3. Schwartz MW , Woods SC , Porte D , Seeley RJ , Baskin DG . Central nervous system control of food intake . Nature . 2000;404:661–671
  4. Harigaya A , Nagashima K , Nako Y , Morikawa A . Relationship between concentration of serum leptin and fetal growth . J Clin Endocrinol Metab . 1997;82:3281–3284
  5. Koistinen HA , Koivisto VA , Andersson S , et al.   Leptin concentration in cord blood correlates with intrauterine growth . J Clin Endocrinol Metab . 1997;82:3328–3330
  6. Schubring C , Siebler T , Kratzsch J , et al.   Leptin serum concentrations in healthy neonates within the first week of life: relation to insulin and growth hormone levels, skin-fold thickness, body mass index and weight . Clin Endocrinol (Oxf) . 1999;51:199–204
  7. Shekhawat PS , Garland JS , Shivpuri C , et al.   Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids . Pediatr Res . 1998;43:338–343
  8. Proietto J , Thorburn AW . Animal models of obesity: theories of aetiology . Baillieres Clin Endocrinol Metab . 1994;8:509–525
  9. Ravelli AC , van Der Meulen JH , Osmond C , Barker DJ , Bleker OP . Obesity at the age of 50 y in men and women exposed to famine prenatally . Am J Clin Nutr . 1999;70:811–816
  10. Singhal A , Farooqi IS , O'Rahilly S , Cole TJ , Fewtrell M , Lucas A . Early nutrition and leptin concentrations in later life . Am J Clin Nutr . 2002;75:993–999
  11. He Q , Horlick M , Thornton J , et al.   Sex and race differences in fat distribution among Asian, African-American, and Caucasian prepubertal children . J Clin Endocrinol Metab . 2002;87:2164–2170
  12. Yeung LP , Wong AC , Wang X , Birmingham CL , Lewicka S , Chanoine JP . Different relationship between anthropometric markers and umbilical cord plasma leptin in Asian and Caucasian neonates . Pediatr Res . 2003;53:1019–1024
  13. Su PH , Wang SL , Chen JY , Lai CP , Jian SH . Serum leptin levels in preterm, healthy and sick-term newborns . Acta Paediatr Taiwan . 2002;43:249–254
  14. Matsuda J , Yokota I , Iida M , et al.   Serum leptin concentration in cord blood: relationship to birth weight and gender . J Clin Endocrinol Metab . 1997;82:1642–1644
  15. Tome MA , Lage M , Camina JP , Garcia-Mayor RV , Dieguez C , Casanueva FF . Sex-based differences in serum leptin concentrations from umbilical cord blood at delivery . Eur J Endocrinol . 1997;137:655–658
  16. Apte SV , Iyengar L . Composition of the human foetus . Br J Nutr . 1972;27:305–312
  17. Frederich RC , Hamann A , Anderson S , Lollmann B , Lowell BB , Flier JS . Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action . Nat Med . 1995;1:1311–1314
  18. Wiedenhoft A , Muller C , Stenger R , Blum WF , Fusch C . Lack of sex difference in cerebrospinal fluid (CSF) leptin levels and contribution of CSF/plasma ratios to variations in body mass index in children . J Clin Endocrinol Metab . 1999;84:3021–3024
  19. Lepercq J , Challier JC , Guerre-Millo M , et al.   Prenatal leptin production: evidence that fetal adipose tissue produces leptin . J Clin Endocrinol Metab . 2001;86:2409–2413
  20. Jaquet D , Leger J , Levy-Marchal C , Oury JF , Czernichow P . Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations . J Clin Endocrinol Metab . 1998;83:1243–1246
  21. Petersen S , Gotfredsen A , Knudsen FU . Lean body mass in small for gestational age and appropriate for gestational age infants . J Pediatr . 1988;113:886–889
  22. Lapillonne A , Guerin S , Braillon P , Claris O , Delmas PD , Salle BL . Diabetes during pregnancy does not alter whole body bone mineral content in infants . J Clin Endocrinol Metab . 1997;82:3993–3997
  23. Enzi G , Zanardo V , Caretta F , Inelmen EM , Rubaltelli F . Intrauterine growth and adipose tissue development . Am J Clin Nutr . 1981;34:1785–1790
  24. Schubring C , Kiess W , Englaro P , et al.   Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight . J Clin Endocrinol Metab . 1997;82:1480–1483
  25. Hassink SG , de Lancey E , Sheslow DV , et al.   Placental leptin: An important new growth factor in intrauterine and neonatal development? . Pediatrics . 1997;100:E1
  26. Christou H , Connors JM , Ziotopoulou M , et al.   Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth . J Clin Endocrinol Metab . 2001;86:935–938
  27. Montague CT , Farooqi IS , Whitehead JP , et al.   Congenital leptin deficiency is associated with severe early-onset obesity in humans . Nature . 1997;387:903–908
  28. Gibson WT , Farooqi IS , Moreau M , et al.   Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy . J Clin Endocrinol Metab . 2004;89:4821–4826
  29. De Bruin NC , Van Velthoven KA , Stijnen T , Juttmann RE , Degenhart HJ , Visser HK . Body fat and fat-free mass in infants: new and classic anthropometric indexes and prediction equations compared with total-body electrical conductivity . Am J Clin Nutr . 1995;61:1195–1205
  30. Wang J , Thornton JC , Russell M , Burastero S , Heymsfield S , Pierson RN . Asians have lower body mass index (BMI) but higher percent body fat than do whites: comparisons of anthropometric measurements . Am J Clin Nutr . 1994;60:23–28
  31. Deurenberg-Yap M , Schmidt G , Van Staveren WA , Deurenberg P . The paradox of low body mass index and high body fat percentage among Chinese, Malays and Indians in Singapore . Int J Obes Relat Metab Disord . 2000;24:1011–1017
  32. Le Stunff C , Le Bihan C , Schork NJ , Bougneres P . A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls . Diabetes . 2000;49:2196–2200
  33. Gardezi AZ , Ziaei YZ , Marashi SM . Microsatellite polymorphism of the human leptin gene and risk of obesity . J Crit Care . 2008;23:440–444
  34. Dahlman I , Arner P . Obesity and polymorphisms in genes regulating human adipose tissue . Int J Obes (Lond) . 2007;31:1629–1641

PII: S1875-9572(09)60073-5

doi: 10.1016/S1875-9572(09)60073-5

Pediatrics & Neonatology
Volume 50, Issue 6 , Pages 255-260 , December 2009