Frequency of Ventilator-associated Pneumonia With 3-day Versus 7-day Ventilator Circuit Changes
Received 27 February 2009; received in revised form 3 June 2009; accepted 22 June 2009.
Background
Ventilator-associated pneumonia (VAP) is a common clinical problem. Previous studies involving adult patient cohorts have assessed various risk factors associated with VAP, including ventilator circuit changes. The objective of this study was to examine the incidence of and risk factors associated with VAP, particularly 3-day versus 7-day ventilator circuit changes, in a pediatric intensive care unit (PICU).
Methods
This was a cohort observational study. Patients hospitalized in the PICU at Chang Gung Children's Hospital between November 2003 and September 2004 were enrolled. Investigators and critical-care specialists evaluated baseline characteristics, incidence of VAP, and related variables from PICU admission until discharge or death.
Results
Of 397 patients initially enrolled, 96 (aged 11–60 months) were available for statistical analysis and were assigned into two groups according to timing of ventilator circuit change: 3-day (n = 46) and 7-day circuit change (n = 50). No statistically significant differences were observed for VAP incidence (13% vs. 16%, p = 0.68) or hospital mortality (22% vs. 36%, p = 0.14) for 3-day versus 7-day circuit change. Incidence of VAP per 1000 ventilation days was 10.75 and 8.41 for 3-day and 7-day circuit change, respectively. Univariate analysis indicated statistical significance for the duration of mechanical ventilation (10.17 ± 16.63 days vs. 18.20 ± 14.99 days, p< 0.001), length of stay in PICU (22.30 ± 20.48 days vs. 37.22 ± 36.79 days, p= 0.0069) and presence of enteral nutrition [7 (15.22%) vs. 23 (46.0%), p = 0.0012].
Conclusion
Weekly circuit change does not contribute to increased rates of VAP in pediatric patients. Long-term studies evaluating risk factors in larger pediatric patient populations are warranted for further conclusive recommendations.
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aDivision of Pediatrics, Far-Eastern Memorial Hospital, Taipei, Taiwan
bDivision of Pediatric Critical Care and Emergency Medicine, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
dDepartment of Respiratory Therapy, Chang Gung Children's Hospital, Taoyuan, Taiwan
eDivision of Pediatric Pulmonology, Chang Gung Children's Hospital, Taoyuan, Taiwan
Corresponding author. Division of Pediatric Critical Care and Emergency Medicine, 2L PICU, Chang Gung Children's Hospital, Chang Gung University College of Medicine, 5 Fu-Hsing Street, Kweishan, Taoyuan 33305, Taiwan
ABSTRACT