Pediatrics & Neonatology
Volume 51, Issue 4 , Pages 242-244, August 2010

Late-onset Group B Streptococcal Meningitis in a Neonate With Early Antibiotic Prophylaxis

  • Ting-Jung Ko

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, National Taiwan University Hospital, No. 8, Chung Shan South Road, Taipei 100, Taiwan
    • ,
  • Wu-Shiun Hsieh

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Po-Ren Hsueh

      Affiliations

    • Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Hung-Chieh Chou

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Chun-Yi Lu

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan

Received 5 May 2009; received in revised form 14 July 2009; accepted 24 August 2009.

Article Outline

An otherwise healthy female baby who had received early postnatal antibiotic prophylaxis because of maternal vaginal group B streptococcal (GBS) colonization died of late-onset GBS meningitis. GBS was isolated from blood and cerebrospinal fluid. Genotyping using pulsed-field gel electrophoresis confirmed that the GBS isolates from the patient were identical to those from her mother's vagina. Susceptibility tests demonstrated no antibiotic resistance. This report provides additional microbiologic evidence indicating that early postnatal antibiotic prophylaxis is not effective in preventing late-onset GBS infections in neonates born to mothers with GBS colonization.

Key Words:  group B streptococcus , late-onset , meningitis , prophylaxis

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Centers for Disease Control and Prevention  . Prevention of perinatal group B streptococcal disease: a public health perspective . MMWR Recomm Rep . 1996;45(RR-7):1–24
  2. Regan JA , Klebanoff MA , Nugent RP . The epidemiology of group B streptococcal colonization in pregnancy. Vaginal Infections and Prematurity Study Group . Obstet Gynecol . 1991;77:604–610
  3. Lin FY , Weisman LE , Troendle J , Adams K . Prematurity is the major risk factor for late-onset group B streptococcus disease . J Infect Dis . 2003;188:267–271
  4. Schrag SJ , Zywicki S , Farley MM , et al.   Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis . N Engl J Med . 2000;342:15–20
  5. Centers for Disease Control and Prevention  . Early-onset and late-onset neonatal group B streptococcal disease-United States, 1996-2004 . MMWR . 2005;54:1205–1208
  6. Centers for Disease Control and Prevention  . Perinatal group B streptococcal disease after universal screening recommendations-United States, 2003-2005 . MMWR . 2007;56:701–705
  7. Wu JH , Chen CY , Tsao PN , Hsieh WS , Chou HC . Neonatal sepsis: a 6-year analysis in a neonatal care unit in Taiwan . Pediatr Neonatol . 2009;50:88–95
  8. Glasgow TS , Young PC , Wallin J , et al.   Association of intra-partum antibiotic exposure and late-onset serious bacterial infections in infants . Pediatrics . 2005;116:696–702
  9. Moylett EH , Fernandez M , Rench MA , Hickman ME , Baker CJ . A 5-year review of recurrent group B streptococcal disease: lessons from twin infants . Clin Infect Dis . 2000;30:282–287
  10. Godambe S , Shah PS , Shah V . Breast milk as a source of late onset neonatal sepsis . Pediatr Infect Dis J . 2005;24:381–382
  11. Green PA , Singh KV , Murray BE , Baker CJ . Recurrent group B streptococcal infections in infants: clinical and microbiologic aspects . J Pediatr . 1994;125:931–938

PII: S1875-9572(10)60046-0

doi:10.1016/S1875-9572(10)60046-0

Pediatrics & Neonatology
Volume 51, Issue 4 , Pages 242-244, August 2010

Article Tools